KlaAtlas ยท Dataset details
PXD040514
Global lactylome reveals lactylation-dependent mechanisms underlying TH17 differentiation in experimental autoimmune uveitis
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3,682
Reidentified Kla sites
1,271
Reidentified Kla proteins
2
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
10090
Sample category
Primary cell
Tissue / cell type
Primary splenic CD4+ T cells from normal control and EAU mice
Experimental condition / comparison
EAU versus normal control mouse CD4+ T-cell lactylome; two selected files explicitly named Control and EAU.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
Pan-Kla antibody with pre-washed beads; peptide immunoaffinity enrichment
Enrichment reagent supplier
PTM Bio
Reagent catalogue information
PTM-1404
Data access
MaxQuant parameter files
PXD040514_mqpar.xml
Raw MS file information
2 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (2 files)
- EE369LPLaB1_Control_Slot1-52_1_21416.d
- EE369LPLaB1_EAU_Slot1-53_1_21418.d
Metadata sources
DOI: 10.1126/sciadv.adh4655
PRIDE PXD040514
Evidence E01-E03
PRIDE PXD040514
Evidence E01-E03
Dataset notes
Sample information and limitations
Two selected group-level acquisitions. Article reports 1 x 10^8 primary CD4+ T cells isolated from more than 10 mice in each group for profiling. The number of independent pools/preparations and exact pool-to-RAW assignment are not specified.