KlaAtlas ยท Dataset details
PXD046495
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
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78
Reidentified Kla sites
33
Reidentified Kla proteins
6
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
10141
Sample category
Animal model
Tissue / cell type
Guinea pig (Cavia porcellus) neurosensory retina; male animals started at 2 weeks of age.
Experimental condition / comparison
Two weeks of monocular form deprivation.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
Pre-washed antibody-bead enrichment of lysine-lactylation-modified peptides
Enrichment reagent supplier
Not specified in accessible enrichment protocol
Reagent catalogue information
Not specified in accessible enrichment protocol
Data access
MaxQuant parameter files
PXD046495_mqpar.xml
Raw MS file information
6 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (6 files)
- GE039LPLaB2_Control_2W_1_Slot1-37_1_221.d
- GE039LPLaB2_Control_2W_2_Slot1-37_1_223.d
- GE039LPLaB2_OD_R_2W_1_Slot1-38_1_225.d
- GE039LPLaB2_OD_R_2W_2_Slot1-38_1_227.d
- GE039LPLaB2_OS_R_2W_1_Slot1-39_1_229.d
- GE039LPLaB2_OS_R_2W_2_Slot1-39_1_231.d
Metadata sources
DOI: 10.1016/j.isci.2024.110606
PRIDE PXD046495
Evidence E01-E04
PRIDE PXD046495
Evidence E01-E04
Dataset notes
Sample information and limitations
6 TIMS-DDA acquisitions; NC=Control_2W_1/2, FDM=OD_R_2W_1/2, contralateral CT=OS_R_2W_1/2. Methods report 6 retinas extracted per group, but pooling and the relation to 2 quantitative columns/group are unreported; independent biological n remains unresolved. Not a fraction series.
Experimental metadata notes
Two weeks of monocular form deprivation. NC: right eyes of untreated normal-control animals; FDM: covered right eyes in the form-deprivation group; CT: exposed left eyes of the same form-deprivation group.