KlaAtlas ยท Dataset details
PXD046631
Serpina3k lactylation protects from cardiac ischemia reperfusion injury
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2,313
Reidentified Kla sites
492
Reidentified Kla proteins
9
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
10090
Sample category
Animal model
Tissue / cell type
Mouse left ventricular myocardium from the infarct area
Experimental condition / comparison
Sham surgery (SHAM), 30 min myocardial ischemia (MI30), and 30 min ischemia followed by 6 h reperfusion (MI_6h).
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
Pre-washed pan-lactylation antibody beads; peptide immunoaffinity enrichment
Enrichment reagent supplier
PTM Bio
Reagent catalogue information
PTM-1404
Data access
MaxQuant parameter files
PXD046631_mqpar.xml
Raw MS file information
9 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (9 files)
- KLa_MI30_1_Slot1-10_1_5761.d
- KLa_MI30_2_Slot1-11_1_5763.d
- KLa_MI30_3_Slot1-12_1_5765.d
- KLa_MI_6h_1_Slot1-4_1_5749.d
- KLa_MI_6h_2_Slot1-5_1_5751.d
- KLa_MI_6h_3_Slot1-6_1_5753.d
- KLa_SHAM_1_Slot1-7_1_5755.d
- KLa_SHAM_2_Slot1-8_1_5757.d
- KLa_SHAM_3_Slot1-9_1_5759.d
Metadata sources
https://doi.org/10.1038/s41467-024-55589-w
https://www.ebi.ac.uk/pride/archive/projects/PXD046631
Methods: ischemia/reperfusion model and lactylome analysis
https://www.ebi.ac.uk/pride/archive/projects/PXD046631
Methods: ischemia/reperfusion model and lactylome analysis
Dataset notes
Sample information and limitations
Three pooled biological replicates per group, each formed by combining myocardium from three mice: nine mice per group and 27 mice total. One selected raw acquisition per pooled biological replicate; nine raws total.