KlaAtlas ยท Dataset details

PXD046800

Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development

Homo sapiens iProX 2024/07
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1,223
Reidentified Kla sites
421
Reidentified Kla proteins
8
Raw MS files

Dataset overview

Dataset accession
PXD046800
Repository
iProX
Publication
39012622
UniProt taxonomy ID
9606
Sample category
Disease tissue
Tissue / cell type
Human hypertrophic scar and patient-matched surrounding normal skin
Experimental condition / comparison
Hypertrophic scar (HSP1-HSP4) versus paired surrounding normal skin (NSP1-NSP4), four patients; no experimental drug treatment.

Experimental information

Acquisition workflow
Standard
MS platform
Orbitrap
Quantification strategy
Label-free
Kla enrichment method
Anti-L-lactyllysine antibody-conjugated agarose beads; peptide immunoaffinity enrichment
Enrichment reagent supplier
PTM BIO
Reagent catalogue information
PTM-1404

Data access

MaxQuant parameter files
PXD046800_mqpar.xml
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Raw MS file information
8 processed acquisition files. Original raw data may be accessed through the source repository.
View in PRIDE
Show raw MS file names (8 files)
  • HFX2_LFQ_QB001_HSP1_1.raw
  • HFX2_LFQ_QB001_HSP2_1.raw
  • HFX2_LFQ_QB001_HSP3_1.raw
  • HFX2_LFQ_QB001_HSP4_1.raw
  • HFX2_LFQ_QB001_NSP1_1.raw
  • HFX2_LFQ_QB001_NSP2_1.raw
  • HFX2_LFQ_QB001_NSP3_1.raw
  • HFX2_LFQ_QB001_NSP4_1.raw
Metadata sources
https://doi.org/10.1021/acs.jproteome.3c00901
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD046800
Abstract; ProteomeXchange dataset description
Dataset notes
Sample information and limitations Four paired patients, with one hypertrophic-scar and one normal-skin biological specimen per patient; four biological replicates per group, eight selected raw files. The matching number in HSP/NSP identifies the patient, not a peptide fraction.