KlaAtlas ยท Dataset details
PXD047535
Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma
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3,167
Reidentified Kla sites
1,189
Reidentified Kla proteins
12
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
9606
Sample category
Disease tissue
Tissue / cell type
Human oral squamous cell carcinoma (OSCC) and paired normal adjacent tissue (NAT)
Experimental condition / comparison
OSCC tumor versus patient-matched normal adjacent tissue; selected patient IDs 3, 4, 5, 7, 9 and 16.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
PTM-1404 resin; peptide immunoaffinity enrichment
Enrichment reagent supplier
PTM-Bio
Reagent catalogue information
PTM-1404
Data access
MaxQuant parameter files
PXD047535_mqpar.xml
Raw MS file information
12 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (12 files)
- XA00303B2LPLa_NAT16_E2_1_17773.d
- XA00303B2LPLa_NAT3_C8_1_17753.d
- XA00303B2LPLa_NAT4_D2_1_17757.d
- XA00303B2LPLa_NAT5_D4_1_17761.d
- XA00303B2LPLa_NAT7_D6_1_17765.d
- XA00303B2LPLa_NAT9_D8_1_17769.d
- XA00303B2LPLa_Tumor16_E3_1_17775.d
- XA00303B2LPLa_Tumor3_D1_1_17755.d
- XA00303B2LPLa_Tumor4_D3_1_17759.d
- XA00303B2LPLa_Tumor5_D5_1_17763.d
- XA00303B2LPLa_Tumor7_D7_1_17767.d
- XA00303B2LPLa_Tumor9_E1_1_17771.d
Metadata sources
https://doi.org/10.1186/s13059-024-03383-8
https://www.ebi.ac.uk/pride/archive/projects/PXD047535
Methods; Fig. 1; Additional files 1-2 (including supplementary information)
https://www.ebi.ac.uk/pride/archive/projects/PXD047535
Methods; Fig. 1; Additional files 1-2 (including supplementary information)
Dataset notes
Sample information and limitations
Six paired biological tissue specimens per group from six patients, one selected acquisition per tissue: 12 raw files total. Numeric suffixes identify paired patients rather than fractions or technical repeats.
Experimental metadata notes
OSCC tumor versus patient-matched normal adjacent tissue; selected patient IDs 3, 4, 5, 7, 9 and 16. The CAL27 lactate-treatment experiments elsewhere in the paper are not represented by these selected raws.