KlaAtlas · Dataset details
PXD056805
H3K14la drives endothelial dysfunction in sepsis‐induced ARDS by promoting SLC40A1/transferrin‐mediated ferroptosis
Back to datasets
1,567
Reidentified Kla sites
565
Reidentified Kla proteins
12
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
10090
Sample category
Animal model
Tissue / cell type
Whole mouse lung tissue lactylome; male C57BL/6J mice, 6-10 weeks, 20-30 g. Do not label the selected MS data as isolated pulmonary endothelial cells.
Experimental condition / comparison
Article compares septic versus control mouse lungs.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
Not verified from accessible original article or repository protocol
Enrichment reagent supplier
Not verified from accessible original article or repository protocol
Reagent catalogue information
Not verified from accessible original article or repository protocol
Data access
MaxQuant parameter files
PXD056805_mqpar.xml
Raw MS file information
12 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (12 files)
- ZD055LPLa_G1M3_Slot1-28_1_3552.d
- ZD055LPLa_G1M4_Slot1-29_1_3554.d
- ZD055LPLa_G1M5_Slot1-30_1_3556.d
- ZD055LPLa_G1M6_Slot1-31_1_3558.d
- ZD055LPLa_G1M8_Slot1-32_1_3560.d
- ZD055LPLa_G1M9_Slot1-33_1_3562.d
- ZD055LPLa_G3M1_Slot1-34_1_3564.d
- ZD055LPLa_G3M2_Slot1-35_1_3566.d
- ZD055LPLa_G3M3_Slot1-36_1_3568.d
- ZD055LPLa_G3M7_Slot1-37_1_3570.d
- ZD055LPLa_G3M8_Slot1-38_1_3572.d
- ZD055LPLa_G3M9_Slot1-39_1_3574.d
Metadata sources
DOI: 10.1002/mco2.70049
PRIDE PXD056805
Evidence E01-E04
PRIDE PXD056805
Evidence E01-E04
Dataset notes
Sample information and limitations
12 selected lung TIMS-DDA acquisitions (6 G1M, 6 G3M), each experiment/fraction=1. Article reports septic/control whole-lung lactylome, but G1/G3 direction, CLP versus LPS model, collection time and independent-mouse/pooling structure are unresolved. Keep condition=unknown and exclude directional contrasts until a code key is obtained.
Experimental metadata notes
Article compares septic versus control mouse lungs. The study uses both CLP/sham and LPS (5 mg/kg)/saline models, but the selected G1M/G3M labels are not explicitly keyed to condition, specific model or collection time.