KlaAtlas ยท Dataset details
PXD058023
Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome
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1,267
Reidentified Kla sites
498
Reidentified Kla proteins
9
Raw MS files
Dataset overview
Dataset accession
Repository
PRIDE
Publication
UniProt taxonomy ID
10090
Sample category
Animal model
Tissue / cell type
Mouse kidney tissue
Experimental condition / comparison
Severe bilateral renal ischemia/reperfusion injury (35 min ischemia): baseline/day 0 versus days 3 and 7.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
Not verified from accessible original article or repository protocol
Enrichment reagent supplier
Not verified from accessible original article or repository protocol
Reagent catalogue information
Not verified from accessible original article or repository protocol
Data access
MaxQuant parameter files
PXD058023_mqpar.xml
Raw MS file information
9 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (9 files)
- SA285LPLa_AKI3d1_Slot1-13_1_8771.d
- SA285LPLa_AKI3d2_Slot1-14_1_8773.d
- SA285LPLa_AKI3d3_Slot2-15_1_8849.d
- SA285LPLa_AKI7d1_Slot1-16_1_8777.d
- SA285LPLa_AKI7d2_Slot1-17_1_8779.d
- SA285LPLa_AKI7d3_Slot1-18_1_8781.d
- SA285LPLa_control1_Slot1-19_1_8783.d
- SA285LPLa_control2_Slot1-20_1_8785.d
- SA285LPLa_control3_Slot1-21_1_8787.d
Metadata sources
https://doi.org/10.1016/j.celrep.2025.116084
https://www.ebi.ac.uk/pride/archive/projects/PXD058023
Abstract; PRIDE project description and sample protocol
https://www.ebi.ac.uk/pride/archive/projects/PXD058023
Abstract; PRIDE project description and sample protocol
Dataset notes
Sample information and limitations
Three biological tissue samples per time point, nine acquisitions. control1-3 correspond to the baseline group; AKI3d1-3 and AKI7d1-3 to days 3 and 7. No selected drug-treatment arms.