KlaAtlas ยท Dataset details
OEP0002852
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
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10,049
Reidentified Kla sites
2,647
Reidentified Kla proteins
110
Raw MS files
Dataset overview
Dataset accession
OEP0002852
Repository
OEP
Publication
UniProt taxonomy ID
9606
Sample category
Disease tissue
Tissue / cell type
Human HBV-related hepatocellular carcinoma (HCC) tumors and matched adjacent non-tumor liver tissue
Experimental condition / comparison
HBV-related HCC tumor versus matched adjacent liver: 58 tumor specimens and 52 adjacent liver specimens from 52 patients.
Experimental information
Acquisition workflow
TIMS-DDA
MS platform
Bruker TIMS
Quantification strategy
Label-free
Kla enrichment method
PTM-1404 antibody beads; peptide immunoaffinity enrichment
Enrichment reagent supplier
PTM Bio
Reagent catalogue information
PTM-1404
Data access
MaxQuant parameter files
OEP0002852_mqpar.xml
Raw MS file information
110 processed acquisition files.
Original raw data may be accessed
through the source repository.
Show raw MS file names (110 files)
- WA141LPLa_P_102_Slot2-36_1_411.d
- WA141LPLa_P_103_Slot2-34_1_407.d
- WA141LPLa_P_106_Slot2-29_1_397.d
- WA141LPLa_P_107_Slot2-27_1_393.d
- WA141LPLa_P_108_Slot2-25_1_389.d
- WA141LPLa_P_110_Slot2-24_1_580.d
- WA141LPLa_P_111_Slot2-22_1_576.d
- WA141LPLa_P_112_Slot2-20_1_572.d
- WA141LPLa_P_113_Slot2-18_1_568.d
- WA141LPLa_P_114_Slot2-16_1_564.d
- WA141LPLa_P_116_Slot2-14_1_560.d
- WA141LPLa_P_118_Slot2-10_1_552.d
- WA141LPLa_P_119_Slot2-8_1_542.d
- WA141LPLa_P_120_Slot2-6_1_538.d
- WA141LPLa_P_121_Slot2-4_1_534.d
- WA141LPLa_P_122_Slot2-2_1_530.d
- WA141LPLa_P_124_Slot2-37_1_526.d
- WA141LPLa_P_125_Slot2-35_1_522.d
- WA141LPLa_P_126_Slot2-33_1_518.d
- WA141LPLa_P_127_Slot2-21_1_488.d
- WA141LPLa_P_128_Slot2-12_1_556.d
- WA141LPLa_P_12_Slot2-31_1_510.d
- WA141LPLa_P_130_Slot2-32_1_403.d
- WA141LPLa_P_36_Slot2-29_1_506.d
- WA141LPLa_P_38_Slot2-27_1_502.d
- WA141LPLa_P_42_Slot2-25_1_498.d
- WA141LPLa_P_43_Slot2-23_1_494.d
- WA141LPLa_P_70_Slot2-19_1_484.d
- WA141LPLa_P_72_Slot2-17_1_480.d
- WA141LPLa_P_73_Slot2-15_1_476.d
- WA141LPLa_P_77_Slot2-13_1_472.d
- WA141LPLa_P_78_Slot2-11_1_468.d
- WA141LPLa_P_79_Slot2-9_1_457.d
- WA141LPLa_P_80_Slot2-7_1_453.d
- WA141LPLa_P_81_Slot2-5_1_449.d
- WA141LPLa_P_84_Slot2-3_1_445.d
- WA141LPLa_P_85_Slot2-49_1_437.d
- WA141LPLa_P_86_Slot2-46_1_431.d
- WA141LPLa_P_87_Slot2-43_1_425.d
- WA141LPLa_P_88_Slot2-41_1_421.d
- WA141LPLa_P_89_Slot2-39_1_417.d
- WA141LPLa_P_90_Slot2-23_1_385.d
- WA141LPLa_P_91_Slot2-21_1_381.d
- WA141LPLa_P_92_Slot2-19_1_377.d
- WA141LPLa_P_93_Slot2-17_1_373.d
- WA141LPLa_P_94_Slot2-15_1_369.d
- WA141LPLa_P_95_Slot2-13_1_365.d
- WA141LPLa_P_96_Slot2-10_1_359.d
- WA141LPLa_P_97_Slot2-8_1_355.d
- WA141LPLa_P_98_Slot2-6_1_351.d
- WA141LPLa_P_99_Slot2-4_1_347.d
- WA141LPLa_P_9_Slot2-2_1_343.d
- WA141LPLa_T1_130_Slot2-30_1_399.d
- WA141LPLa_T1_84_Slot2-2_1_443.d
- WA141LPLa_T1_85_Slot2-48_1_435.d
- WA141LPLa_T1_86_Slot2-44_1_427.d
- WA141LPLa_T1_89_Slot2-38_1_415.d
- WA141LPLa_T1_95_Slot2-11_1_361.d
- WA141LPLa_T2_130_Slot2-31_1_401.d
- WA141LPLa_T2_84_Slot2-1_1_441.d
- WA141LPLa_T2_85_Slot2-47_1_433.d
- WA141LPLa_T2_86_Slot2-45_1_429.d
- WA141LPLa_T2_89_Slot2-37_1_413.d
- WA141LPLa_T2_95_Slot2-12_1_363.d
- WA141LPLa_T_102_Slot2-35_1_409.d
- WA141LPLa_T_103_Slot2-33_1_405.d
- WA141LPLa_T_106_Slot2-28_1_395.d
- WA141LPLa_T_107_Slot2-26_1_391.d
- WA141LPLa_T_108_Slot2-24_1_387.d
- WA141LPLa_T_110_Slot2-23_1_578.d
- WA141LPLa_T_111_Slot2-21_1_574.d
- WA141LPLa_T_112_Slot2-19_1_570.d
- WA141LPLa_T_113_Slot2-17_1_566.d
- WA141LPLa_T_114_Slot2-15_1_562.d
- WA141LPLa_T_116_Slot2-13_1_558.d
- WA141LPLa_T_118_Slot2-9_1_550.d
- WA141LPLa_T_119_Slot2-7_1_540.d
- WA141LPLa_T_120_Slot2-5_1_536.d
- WA141LPLa_T_121_Slot2-3_1_532.d
- WA141LPLa_T_122_Slot2-1_1_528.d
- WA141LPLa_T_124_Slot2-36_1_524.d
- WA141LPLa_T_125_Slot2-34_1_520.d
- WA141LPLa_T_126_Slot2-32_1_512.d
- WA141LPLa_T_127_Slot2-20_1_486.d
- WA141LPLa_T_128_Slot2-11_1_554.d
- WA141LPLa_T_12_Slot2-30_1_508.d
- WA141LPLa_T_36_Slot2-28_1_504.d
- WA141LPLa_T_38_Slot2-26_1_500.d
- WA141LPLa_T_42_Slot2-24_1_496.d
- WA141LPLa_T_43_Slot2-22_1_492.d
- WA141LPLa_T_70_Slot2-18_1_482.d
- WA141LPLa_T_72_Slot2-16_1_478.d
- WA141LPLa_T_73_Slot2-14_1_474.d
- WA141LPLa_T_77_Slot2-12_1_470.d
- WA141LPLa_T_78_Slot2-10_1_459.d
- WA141LPLa_T_79_Slot2-8_1_455.d
- WA141LPLa_T_80_Slot2-6_1_451.d
- WA141LPLa_T_81_Slot2-4_1_447.d
- WA141LPLa_T_87_Slot2-42_1_423.d
- WA141LPLa_T_88_Slot2-40_1_419.d
- WA141LPLa_T_90_Slot2-22_1_383.d
- WA141LPLa_T_91_Slot2-20_1_379.d
- WA141LPLa_T_92_Slot2-18_1_375.d
- WA141LPLa_T_93_Slot2-16_1_371.d
- WA141LPLa_T_94_Slot2-14_1_367.d
- WA141LPLa_T_96_Slot2-9_1_357.d
- WA141LPLa_T_97_Slot2-7_1_353.d
- WA141LPLa_T_98_Slot2-5_1_349.d
- WA141LPLa_T_99_Slot2-3_1_345.d
- WA141LPLa_T_9_Slot2-1_1_341.d
Metadata sources
https://doi.org/10.1038/s42255-022-00710-w
Abstract; Extended Data Figs. 1-2; Reporting Summary (including supplementary information)
Abstract; Extended Data Figs. 1-2; Reporting Summary (including supplementary information)
Dataset notes
Sample information and limitations
110 biological tissue specimens from 52 patients, with one selected raw acquisition per specimen: 52 adjacent liver, 46 single tumor, and 12 tumor specimens from six multifocal cases. T1/T2 denote distinct tumor foci from the same patient, not technical replicates or peptide fractions.
Experimental metadata notes
HBV-related HCC tumor versus matched adjacent liver: 58 tumor specimens and 52 adjacent liver specimens from 52 patients. Six patients contributed two separate tumor foci.